Cell therapy for autoimmune diseases
نویسندگان
چکیده
منابع مشابه
Cell therapy for autoimmune diseases
Cell therapy, pioneered for the treatment of malignancies in the form of bone marrow transplantation, has subsequently been tested and successfully employed in autoimmune diseases. Autologous haemopoietic stem cell transplantation (HSCT) has become a curative option for conditions with very poor prognosis such as severe forms of scleroderma, multiple sclerosis, and lupus, in which targeted ther...
متن کاملP 53: Stem Cell Therapy for Treatment of Autoimmune Diseases (with Emphasis on Multiple Sclerosis)
Autoimmune diseases have been described as an interesting and poorly understood group of disorders. There are many challenges in the respective scientific societies concerning the nature, causes and the therapeutic approaches of these diseases. In accordance with the evidences the nature and etiology of these disorders is multifactorial and complex but the clearest definition could be expressed...
متن کاملRationale for cell therapy for autoimmune diseases
Cell therapy, pioneered for the treatment of malignancies in the form of bone marrow transplantation, has subsequently been tested and successfully employed in autoimmune diseases. Autologous haemopoietic stem cell transplantation (HSCT) has become a curative option for conditions with very poor prognosis such as severe forms of scleroderma, multiple sclerosis, and lupus, in which targeted ther...
متن کاملStem cell therapy for severe autoimmune diseases
The interest in autoimmune diseases (ADs) is increasing exponentially (1, 2). Their estimated prevalence in Western countries ranges from 3% to 70% of the general population (3). Autoimmunity coincides with the loss of tolerance to the self (4); it is thought of as a persistent failure of an integrated fabric of components rather than the adverse consequence of a specific “forbidden clone” (5)....
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Almost all current therapeutic concepts in autoimmune diseases are based on the systemic suppression of immune functions and are not curative. The recent introduction of biologicals such as tumour necrosis factor blocking antibodies or receptors has added greater specificity to efficient management of disease by targeted suppression of rheumatic inflammation. It is evident, however, that only t...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2007
ISSN: 1478-6354
DOI: 10.1186/ar2128